Related Experiment Video
Updated: Feb 7, 2026

Author Spotlight: Advancing Gene Editing in Bamboo Leaves for Sustainable Plastic Alternatives
Published on: August 18, 2023
GOstat: find statistically overrepresented Gene Ontologies within a group of genes
Tim Beissbarth1, Terence P Speed
1Walter and Eliza Hall Institute of medical Research, 1G Royal Parade, Parkville, Vic 3050, Australia. beissbarth@wehi.edu.au
Summary:
Modern experimental techniques, as for example DNA microarrays, as a result usually produce a long list of genes, which are potentially interesting in the analyzed process. In order to gain biological understanding from this type of data, it is necessary to analyze the functional annotations of all genes in this list. The Gene-Ontology (GO) database provides a useful tool to annotate and analyze the functions of a large number of genes. Here, we introduce a tool that utilizes this information to obtain an understanding of which annotations are typical for the analyzed list of genes. This program automatically obtains the GO annotations from a database and generates statistics of which annotations are overrepresented in the analyzed list of genes. This results in a list of GO terms sorted by their specificity.
Availability:
Our program GOstat is accessible via the Internet at http://gostat.wehi.edu.au
More Related Videos
10:34Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
Published on: April 14, 2010
12:55Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency
Published on: January 6, 2010
Related Concept Videos
Gene Flow
Gene Families
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Gene Therapy
Gene Conversion
What is Gene Expression?
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
Organization of Genes