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Photo recall effect in association with cefazolin.
Luis A Garza1, Elisa K Yoo, Jacqueline M Junkins-Hopkins
1Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, USA.
Cutis
|February 18, 2004
Summary
Radiation recall dermatitis can recur with chemotherapy. This study documents a rare case of photo recall dermatitis triggered by the antibiotic cefazolin, confirmed by biopsy.
Area of Science:
- Dermatology
- Pharmacology
- Oncology
Background:
- Radiation recall dermatitis is a known phenomenon where skin previously treated with radiation therapy reacts to systemic treatments like chemotherapy.
- Photo recall reactions, triggered by sun exposure and certain medications, are less common but documented.
- Cefazolin is a widely used antibiotic with a generally favorable safety profile.
Observation:
- A patient presented with a skin reaction following treatment with cefazolin.
- The reaction occurred in an area previously affected by radiation therapy.
- Clinical presentation and biopsy findings were consistent with a phototoxic eruption.
Findings:
- The patient developed a photo recall reaction after receiving cefazolin.
- Histopathological examination of a shave biopsy confirmed a mild phototoxic eruption.
- This case suggests cefazolin can induce photo recall reactions, particularly in previously irradiated skin.
Implications:
- This case expands the spectrum of drugs known to cause photo recall reactions.
- Clinicians should consider cefazolin as a potential trigger for photo recall dermatitis in susceptible patients.
- Further investigation may be warranted to understand the mechanisms underlying cefazolin-induced photo recall.