Related Experiment Video
Updated: Aug 14, 2026
Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
Published on: January 16, 2015
[DDT/DDE concentrations and risk of hypospadias. Pilot case-control study]
Silvia Flores-Luévano1, Paulina Farías, Mauricio Hernández
1Instituto Mexicano del Seguro Social, Delegación Ciudad Juárez, Chihuahua, México. silflor@prodigy.net.mx
Objective:
To evaluate the association between maternal serum DDT/DDE levels and risk of hypospadias.
Material And Methods:
A case-control study in Mexico City was conducted during 1997-1999 among 41 subjects with hypospadias and 28 controls. Blood samples were obtained from study subjects. Information was obtained using a standardized questionnaire. Data were analyzed using multivariate logistic regression models.
Results:
Maternal DDT and DDE levels showed no association with hypospadias (OR 1.13; 95% CI 0.24-5.29 and OR = 0.48; 95% CI 0.15-1.60, respectively). Associated factors were older age of mothers (OR 8.69; 95% CI 1.69-44.9), and working during pregnancy (OR 4.68; 95% CI 1.15-18.9).
Conclusions:
Information about the endocrine effects of different levels of DDT/DDE in human subjects is scarce; dosage may be a determinant factor of the type of effect. The English version of this paper is available at:http://www.insp.mx/salud/index.html.
