Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Clinical features in osteosarcoma and prognostic implications].

Angela Rech1, Cláudio G Castro, Jane Mattei

  • 1Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.

Jornal De Pediatria
|February 24, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cholangiocarcinoma in the Era of Precision Medicine: Emerging Insights and Therapeutic Strategies.

Current pharmaceutical design·2026
Same author

Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage.

Nature communications·2026
Same author

Mucosal Melanoma: Treatment Strategies for a Heterogeneous Disease.

Current pharmaceutical design·2026
Same author

Adjuvant therapy in mucosal melanoma: a single-center experience and review of the literature.

Melanoma research·2025
Same author

A Versatile Ribo-seq Workflow for Enhanced Analysis of Ribosome Dynamics.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Decoding epithelial regeneration in the cornea: multi-omic analysis reveals cellular plasticity as central mechanism.

Cellular & molecular biology letters·2025
Same journal

Cross-cultural adaptation into Brazilian portuguese of an international questionnaire for the assessment of cardiopulmonary resuscitation knowledge among adolescents.

Jornal de pediatria·2026
Same journal

Evaluation of ChatGPT's reliability in answering questions about short stature and growth failure.

Jornal de pediatria·2026
Same journal

Validity of the Khamis-Roche method, relative to bone age, in Portuguese children and adolescents from 11 to 15 years.

Jornal de pediatria·2026
Same journal

Urogenital congenital anomalies in children under 9 years: global disease burden analysis and projections, 1990-2021.

Jornal de pediatria·2026
Same journal

Intraventricular hemorrhage in preterm newborns: a multicenter study in four Brazilian hospitals.

Jornal de pediatria·2026
Same journal

Agreement between Fenton and intergrowth curves in assessing birth weight of preterm infants: Bland-Altman analysis by degree of prematurity and birth weight for gestational age.

Jornal de pediatria·2026
See all related articles

Metastatic osteosarcoma at diagnosis, elevated serum lactic dehydrogenase, and poor tumor necrosis predict a worse prognosis in children and adolescents. These factors indicate aggressive disease or late diagnosis, impacting survival rates.

Area of Science:

  • Pediatric Oncology
  • Skeletal Oncology
  • Cancer Prognostics

Context:

  • Osteosarcoma is a primary bone cancer predominantly affecting children and adolescents.
  • Clinical features and prognostic indicators require ongoing investigation to improve patient outcomes.
  • Understanding disease patterns in specific populations is crucial for tailored treatment strategies.

Purpose:

  • To identify clinical features associated with osteosarcoma in pediatric and adolescent patients.
  • To investigate the prognostic influence of these clinical features on disease outcomes.
  • To evaluate survival rates and identify predictors of unfavorable prognosis in this demographic.

Summary:

  • This study reviewed 50 pediatric and adolescent osteosarcoma cases, analyzing clinical features and treatment outcomes.

Related Experiment Videos

  • Key prognostic factors identified include presence of metastases at diagnosis, serum lactic dehydrogenase levels (>1,000 UI/ml), and tumor necrosis (<90%).
  • Overall 5-year survival was 33.2%, with significantly poorer outcomes for metastatic patients (0% 5-year event-free survival).

    • Impact:

    • Identifies critical prognostic markers for osteosarcoma in young patients, aiding in risk stratification.
    • Highlights a potentially aggressive disease pattern or challenges with late diagnosis in the studied population.
    • Informs clinical decision-making and emphasizes the need for early detection and aggressive management of metastatic osteosarcoma.