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Signal transduction: the nuclear target.

L D Kerr1, J Inoue, I M Verma

  • 1Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186-5800.

Current Opinion in Cell Biology
|June 1, 1992
PubMed
Summary
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Fos and Jun proteins regulate gene transcription via AP-1 sites, with their activity modulated by post-translational modifications. The rel/NF-kappa B family

Area of Science:

  • Molecular Biology
  • Gene Regulation
  • Protein Interactions

Background:

  • Fos and Jun heterodimers are key transcription factors activating genes with AP-1 sites.
  • Post-translational modifications regulate the activity of Fos and Jun proteins.
  • The rel/NF-kappa B family of transcription factors controls gene expression.

Purpose of the Study:

  • To elucidate the regulatory mechanisms of Fos/Jun and rel/NF-kappa B transcriptional factors.
  • To understand the role of I kappa B in controlling rel/NF-kappa B activity.

Main Methods:

  • Analysis of protein interactions and post-translational modifications.
  • Investigating the role of specific protein motifs in transcriptional regulation.

Main Results:

Related Experiment Videos

  • Fos and Jun activity is modulated by post-translational modifications.
  • I kappa B sequesters rel/NF-kappa B in the cytoplasm, inhibiting its activity.
  • The ankyrin repeat motif in I kappa B is crucial for binding to rel/NF-kappa B.

Conclusions:

  • Post-translational modifications are critical for regulating Fos and Jun activity.
  • The I kappa B protein, via its ankyrin repeat motif, directly controls rel/NF-kappa B nuclear translocation and transcriptional activity.