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Updated: Aug 26, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis of novel 2,3-dihydro-1,4-dioxino[2,3-g]quinoline derivatives as potential antitumor agents
M T Vázquez1, M Romero, M D Pujol
1Laboratori de Química Farmacèutica, Unitat associada al CSIC, Facultat de Farmàcia, Universitat de Barcelona, Av. Diagonal 643, E-08028-Barcelona, Spain.
Abstract:
New dioxinoquinolines (1-8) have been synthesized and their antiproliferative properties have been tested against several cell lines. The treatment of the 6-acetamido-2,3-dihydro-1,4-benzodioxine (10) with phosphorous oxychloride in the presence of DMF leads to a mixture of linear and angular tricyclic compounds. The key intermediates were modified and cyclized giving the corresponding dioxinoquinolines. In general, these compounds have a moderate citotoxycity.

