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A new HLA-DRB111 allele, DRB11144, identified by cloning and sequencing

S Nesci¹, O Buffi, A Iliescu

¹Laboratorio di Ricerca di Onco-Ematologia, Dipartimento di Onco-Ematologia, Azienda Ospedale 'San Salvatore', Pesaro, Italy. s.nesci@ospedalesansalvatore.it

Tissue Antigens

|March 3, 2004

Abstract:

We report here the identification of a novel DRB1*11 allele, DRB1*1144, identified during sequence-based HLA-DRB1 typing. Molecular cloning and direct sequencing confirmed that the new allele is identical to DRB1*110401 at exon 2, except for a single nucleotide substitution (GTG-->GCG) changing codon 38 from Valine to Alanine.

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