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Confirmation of the HLA-DPA1*01:03:35 Allele by Next-Generation Sequencing
M Troiano1, A G Bianculli1, F Besi1
1Laboratory of Immunogenetics and Transplant, Department of Oncohematology and Cell and Gene Therapy, IRCCS Bambin Gesù Pediatric Hospital, Rome, Italy.
HLA
|May 16, 2026
Summary
A new Human Leukocyte Antigen (HLA) allele, HLA-DPA1*01:03:35, was identified. It differs from a known allele by one synonymous mutation in exon 3.
Area of Science:
- Immunogenetics
- Molecular Biology
Background:
- Human Leukocyte Antigen (HLA) genes are crucial for immune response.
- Allelic variations within HLA genes can impact immune function and disease susceptibility.
Purpose of the Study:
- To characterize a novel HLA-DPA1 allele.
- To identify genetic variations in the HLA-DPA1 gene.
Main Methods:
- Sequence analysis of the HLA-DPA1 gene.
- Comparison of the novel allele sequence with existing HLA database entries.
Main Results:
- A new allele, HLA-DPA1*01:03:35, was identified.
- This allele contains a single synonymous mutation in exon 3 compared to HLA-DPA1*01:03:01:01.
Conclusions:
- The discovery of HLA-DPA1*01:03:35 expands the known HLA allele repertoire.
- This finding contributes to a more comprehensive understanding of HLA polymorphism.
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