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Pigmented central neurocytoma.

Tim-Rasmus Kiehl1, Steven N Kalkanis, David N Louis

  • 1Department of Pathology, WRN2, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Acta Neuropathologica
|March 3, 2004
PubMed
Summary
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This study details a rare central neurocytoma case in a 60-year-old woman. The tumor exhibited unusual pigment, later identified as hemosiderin, marking the first reported instance of this specific pigmentation in central neurocytoma.

Area of Science:

  • Neuropathology
  • Neuro-oncology
  • Histopathology

Background:

  • Central neurocytoma is a rare, low-grade neuronal tumor typically found in the lateral ventricles.
  • Pigmented central neurocytoma is an uncommon variant, with previous cases reporting lipofuscin or neuromelanin.
  • Hemosiderin deposition in central neurocytoma has not been previously documented.

Purpose of the Study:

  • To report a unique case of central neurocytoma with hemosiderin pigment.
  • To characterize the histopathological and immunohistochemical features of this rare variant.
  • To differentiate this case from previously described pigmented central neurocytomas.

Main Methods:

  • Case presentation of a 60-year-old female with neurological symptoms.
  • Preoperative imaging (MRI) to evaluate the intraventricular mass.

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  • Histopathological examination including H&E staining, synaptophysin immunohistochemistry, and special stains for pigment identification (iron, melanin).

    • Main Results:

    • A heterogeneous, hypervascular, partially cystic mass was identified in the left lateral ventricle.
    • Histopathology confirmed central neurocytoma with positive synaptophysin staining.
    • Tumor cells contained abundant pigment identified as hemosiderin (iron deposition), with no evidence of melanin.

    Conclusions:

    • This case represents the first documented instance of central neurocytoma pigmented by hemosiderin.
    • The presence of hemosiderin should be considered in the differential diagnosis of pigmented central neurocytoma.
    • Further research may elucidate the mechanism and clinical significance of hemosiderin deposition in this neoplasm.