Nitric oxide, lipid peroxides, and uric acid levels in pre-eclampsia and eclampsia

The aim was to study the role of nitric oxide (NO), lipid peroxides (LPX), and uric acid in pre-eclampsia and eclampsia. Plasma levels of NO metabolites (nitrite+nitrate), malonyldialdehyde (MDA), and uric acid and erythrocyte MDA levels were compared between normal pregnant, pre-eclamptic, and eclamptic pregnant women in third trimester. Student's t-test was used for statistical evaluation. Plasma NO metabolites levels were higher in eclamptic group (35.7 +/- 16.5 micromol/liter, p < 0.05) but not in pre-eclamptic group (22.1 +/- 10.8 micromol/liter) than control group (18.8 +/- 6.9 micromol/liter). Plasma MDA and uric acid concentrations were higher in preeclamptic (4.4 +/- 1.7 nmol/ml, p < 0.05; 0.45 +/- 0.11 mmol/liter, p < 0.05, respectively) and eclamptic (5.8 +/- 1.9 nmol/ml, p < 0.05; 0.47 +/- 0.12 mmol/liter, p < 0.05) groups compared with control group (3.0 +/- 1.3 nmol/ml; 0.35 +/- 0.06 mmol/liter). Erythrocytes MDA concentrations were higher only in eclamptic group (174.4 +/- 62 nmol/gHb, p < 0.05) than control group (139.2 +/- 49.5 nmol/gHb). These results suggest that NO, LPX, and uric acid are important factors in the pathogenesis of pre-eclampsia and eclampsia, and that NO production and LPX are directly related to the severity of disease.