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[Lipoid nephrosis in childhood].
1Service de néphrologie pédiatrique, hôpital Necker-Enfants malades, 75743 Paris Cedex 15. niaudet@necker.fr
La Revue Du Praticien
|March 11, 2004
Summary
Idiopathic nephrotic syndrome, a common childhood kidney disease, presents with varied renal lesions and potential complications. Treatment response dictates prognosis, with resistance risking kidney failure.
Area of Science:
- Pediatric Nephrology
- Glomerular Diseases
- Renal Pathology
Context:
- Lipoid nephrosis, or idiopathic nephrotic syndrome (INS), is the most frequent glomerular disease in childhood.
- INS is characterized by nephrotic syndrome with minimal or unspecific renal biopsy findings like FSGS or DPGN.
- Complications include infections, thrombo-embolic events, hypovolemia, and treatment-related adverse effects from steroids and immunosuppressants.
Purpose:
- To define lipoid nephrosis (idiopathic nephrotic syndrome) in children.
- To outline the spectrum of renal pathology associated with INS.
- To detail the complications and prognostic factors of INS.
Summary:
- INS presents with nephrotic syndrome and variable renal histology.
- Key complications include infections, thromboembolism, and treatment side effects.
- Prognosis hinges on steroid responsiveness; resistance carries a 50% risk of renal failure within 5 years.
Impact:
- Highlights the significant morbidity associated with childhood INS.
- Emphasizes the critical role of steroid response in determining long-term outcomes.
- Informs clinical management strategies and risk stratification for pediatric patients with INS.