Related Experiment Video

Updated: Aug 25, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Glycated haemoglobin and associated variables in diabetics: Ilorin experience

S A Adebisi1, E K Oghagbon, A K Jimoh

  • 1Department of Chemical Pathology and Immunology, Faculty of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria.

West African Journal of Medicine
|March 11, 2004
PubMed

Insights

This study on type 2 diabetes mellitus found that while most patients had elevated hemoglobin glycation (HbA1c), factors like age, sex, and disease duration had little impact. Body mass index showed a poor correlation, but glycation appeared to decrease with higher BMI.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Clinical Chemistry

Background:

  • Type 2 diabetes mellitus (T2DM) is a global health concern characterized by hyperglycemia.
  • Glycated hemoglobin (HbA1c) is a key biomarker for assessing long-term glycemic control in T2DM patients.
  • Understanding factors influencing HbA1c is crucial for effective diabetes management.

Purpose of the Study:

  • To investigate the extent of hemoglobin glycation in T2DM patients.
  • To identify potential influencing factors such as age, sex, disease duration, and body mass index (BMI).

Main Methods:

  • A cohort of 150 patients with T2DM was studied.
  • HbA1c levels were measured.
  • Data on patient demographics (age, sex), disease duration, and BMI were collected and analyzed.

Main Results:

  • The mean HbA1c level was 8.0%, with approximately 64% of subjects exceeding 7.2%.
  • Sex, age, and disease duration did not show a significant effect on HbA1c levels.
  • A poor correlation was observed between BMI and HbA1c, though a trend suggested decreased glycation with increasing BMI.
  • Nearly 70% of female diabetics were overweight.

Conclusions:

  • Glycemic control, as indicated by HbA1c, is suboptimal in a significant portion of the studied T2DM population.
  • Traditional factors like age, sex, and disease duration appear to have limited influence on HbA1c in this cohort.
  • The relationship between BMI and glycemic control is complex, with a potential inverse association observed between BMI and HbA1c.

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...