Related Experiment Video

Updated: Aug 25, 2026

Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer
07:59

Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

Genomic surgery for lung cancer

David S Schrump1

  • 1Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. david_Schrump@nih.gov

The Journal of Surgical Research
|March 12, 2004
PubMed

Insights

Epigenetic modifications like DNA methylation and histone acetylation are key in cancer development. This review explores using chromatin remodeling agents to treat thoracic malignancies by inducing cell death and boosting immune response.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • Reversible chromatin structure alterations influence gene expression during cancer.
  • Epigenetic processes, including DNA methylation and histone acetylation, are critical regulators of chromatin structure.
  • These epigenetic mechanisms are interconnected and modulated by signal transduction pathways.

Purpose of the Study:

  • To review recent advancements in cancer epigenetics.
  • To focus on the therapeutic potential of chromatin remodeling agents in thoracic malignancies.
  • To explore how these agents can induce apoptosis and enhance anti-tumor immunity.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of epigenetic mechanisms in cancer development.
  • Evaluation of chromatin remodeling agents as potential cancer therapeutics.

Main Results:

  • Emerging evidence links chromatin alterations to gene expression changes in cancer.
  • DNA methylation and histone acetylation are key epigenetic regulators.
  • Chromatin remodeling agents show promise for inducing apoptosis and enhancing immunogenicity.

Conclusions:

  • Epigenetic dysregulation plays a significant role in thoracic malignancies.
  • Chromatin remodeling agents represent a promising therapeutic strategy.
  • Targeting epigenetic modifications could improve cancer treatment outcomes by enhancing apoptosis and immune response.

More Related Videos

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...