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Bull's-eye maculopathy associated with quinacrine therapy for malaria
1Charlotte Eye, Ear, Nose, and Throat Associates, Charlotte, North Carolina 28210, USA. djbrowining@carolina.rr.com
Purpose:
To report a side effect of quinacrine therapy for malaria.
Design:
Case report.
Methods:
Review of clinical chart and photographs.
Setting:
Private retina practice.
Results:
A patient developed a bilaterally symmetric bull's-eye maculopathy 45 years after taking quinacrine for 18 months as prophylaxis against malaria. Progression of the clinical picture was documented over 15 years of follow-up. The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.
Conclusions:
Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.
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