Related Experiment Video
Updated: Aug 25, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
[Topical immunomodulators: a therapeutic option for oral cicatricial pemphigoid]
T Assmann1, T Burchardt, J Becker
1Hautklinik, Universitätsklinikum Düsseldorf, Düsseldorf.
Abstract:
Oral cicatricial pemphigoid is a chronic autoimmune blistering disease which affects predominantly the gingiva and the buccal mucosa. The pathogenesis of this disease is still incompletely understood; however, there is compelling evidence that cicatricial pemphigoid might be mediated by T lymphocytes. Therefore, we performed immunomodulatory therapy with topical tacrolimus in patients with long-standing, therapy-resistant oral cicatricial pemphigoid. Following 3 months of treatment, complete healing and ongoing remission could be achieved.
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