Search research articles

Search research articles

Related Experiment Videos

Practical selection of antiemetics.

Zachary A Flake¹, Robert D Scalley, Austin G Bailey

¹Fort Collins Family Medicine Residency Program, Fort Collins, Colorado 80524, USA. flakza@pvhs.org

American Family Physician

|March 17, 2004

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Practical selection of antiemetics in the ambulatory setting.

American family physician·2015

Same author

Clinical inquiries. Is DEET safe for children?

The Journal of family practice·2005

Same author

Treatment of ethylene glycol poisoning.

American family physician·2002

Same journal

For Post-stent Patients With Atherosclerotic Coronary Vascular Disease Who Are Taking an Anticoagulant, Adding Aspirin Worsens Outcomes.

American family physician·2026

Same journal

Nausea and Vomiting During Pregnancy.

American family physician·2026

Same journal

Metabolic Dysfunction-Associated Steatotic Liver Disease: Diagnosis and Management.

American family physician·2026

Same journal

Aerobic Exercise Is the Better Exercise Modality for Knee Osteoarthritis.

American family physician·2026

Same journal

Overscreening Leads to Overdiagnosis of MASLD.

American family physician·2026

Same journal

Type 2 Diabetes: Outpatient Insulin Management.

American family physician·2026

See all related articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Understanding nausea pathophysiology and antiemetic mechanisms aids physicians in improving therapy. Targeting dopamine, serotonin, histamine, and acetylcholine pathways enhances treatment efficacy for various nausea causes.

Area of Science:

Pharmacology
Gastroenterology
Neurology

Background:

Nausea and vomiting are common symptoms with diverse etiologies.
Effective management requires understanding underlying pathophysiological mechanisms.
Current antiemetic therapies target specific neurotransmitter pathways.

Purpose of the Study:

To elucidate the pathophysiology of nausea and vomiting.
To review the mechanisms of action for various antiemetic drug classes.
To guide family physicians in selecting cost-effective and efficacious antiemetic therapies.

Main Methods:

Review of neurotransmitter involvement in nausea pathways (dopamine, serotonin, histamine, acetylcholine).
Analysis of antiemetic drug classes targeting these pathways.

Related Experiment Videos

Evaluation of therapeutic indications for antihistamines, anticholinergics, dopamine antagonists, and serotonin antagonists.

Main Results:

Visceral stimulation involves dopamine and serotonin.
Vestibular and central nervous system causes involve histamine and acetylcholine.
Dopamine and serotonin antagonists are effective for chemoreceptor trigger zone stimulation and gastrointestinal causes.
Antihistamines and anticholinergics are indicated for vestibular and CNS-related nausea.

Conclusions:

Targeting specific neurotransmitter pathways (dopamine, serotonin, histamine, acetylcholine) is key to effective nausea management.
Different antiemetic classes are suited for distinct etiological causes of nausea.
Complementary therapies like ginger and vitamin B6 show variable efficacy for pregnancy-induced nausea.