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[Photochemotherapy for pityriasis lichenoides: 3 cases].
I Pansé1, E Bourrat, M Rybojad
1Service de Dermatologie, Hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris. isabelle.panse@sls.ap-hop-paris.fr
Annales De Dermatologie Et De Venereologie
|March 18, 2004
Summary
Photochemotherapy, a novel treatment for pityriasis lichenoides, demonstrated significant effectiveness in three pediatric and young adult cases. This approach offers a promising new therapeutic option for this rare skin condition.
Area of Science:
- Dermatology
- Photobiology
Context:
- Pityriasis lichenoides is a rare, chronic skin condition affecting children and young adults, with limited effective treatment options.
- Existing therapies for pityriasis lichenoides, including topical corticosteroids, antibiotics, UVB, and dapsone, have shown limited success.
Purpose:
- To evaluate the efficacy of photochemotherapy as a novel treatment for pityriasis lichenoides.
- To report the first use of photochemotherapy in managing pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica.
Summary:
- Three patients with pityriasis lichenoides (two et varioliformis acuta, one chronica) were treated with acitretin combined with PUVA (photochemotherapy).
- All patients experienced dramatic improvement within weeks, despite previous treatment failures with conventional therapies.
- Photochemotherapy, specifically PUVA, proved highly effective in resolving both papular, necrotic, and scaly lesions associated with pityriasis lichenoides.
Impact:
- Photochemotherapy presents a potentially effective new therapeutic avenue for pityriasis lichenoides, a condition known for its scarring and significant psychosocial impact.
- Further research is warranted to define optimal photochemotherapy protocols for pityriasis lichenoides.