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Updated: Aug 25, 2026

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
[Role of nitric oxide in tumor growth]
V N Zaporozhan1, A I Gozhenko, T V Korneenko
1Odessa State Medical University.
Abstract:
This review article will analyze the role of nitric oxide in antiblastomous organism resistance, in particular some mechanisms of NO-mediated apoptosis in different cells and NO involvement in etiological mechanisms as well as tumor growth promotion. The possible mechanisms of nitric oxide dual effect are discussed. The data about NO as a mediator in different methods of cancer treatment are given. In conclusion, we have determined some principles of application of NO-modulating agents in cancer therapy.
Insights
Nitric oxide (NO) plays a dual role in cancer, potentially aiding resistance and treatment but also promoting tumor growth. Understanding NO
Area of Science:
- Biochemistry
- Immunology
- Oncology
Context:
- Nitric oxide (NO) is a molecule with complex roles in biological systems.
- Its involvement in cancer is multifaceted, influencing both resistance and progression.
- Understanding NO's mechanisms is crucial for developing effective cancer therapies.
Purpose:
- To review the dual role of nitric oxide (NO) in cancer.
- To analyze NO-mediated apoptosis and its involvement in tumor etiology and growth.
- To discuss NO's potential as a mediator in cancer treatment strategies.
Summary:
- Nitric oxide (NO) exhibits a dual effect in cancer, acting as both an anti-tumorigenic and pro-tumorigenic factor.
- Mechanisms of NO-mediated apoptosis and its role in tumor development are explored.
- The review examines NO's involvement in various cancer treatment modalities.
Impact:
- Provides insights into the complex functions of NO in cancer biology.
- Highlights the potential of NO-modulating agents for novel cancer therapeutic strategies.
- Informs the application of NO-based therapies for improved patient outcomes.
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