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Socializing with the neighbors: stem cells and their niche
Elaine Fuchs1, Tudorita Tumbar, Geraldine Guasch
1Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA. fuchslb@rockefeller.edu
Abstract:
The potential of stem cells in regenerative medicine relies upon removing them from their natural habitat, propagating them in culture, and placing them into a foreign tissue environment. To do so, it is essential to understand how stem cells interact with their microenvironment, the so-called stem cell niche, to establish and maintain their properties. In this review, we examine adult stem cell niches and their impact on stem cell biology.
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