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The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
The changing evolution of renal tumours: a single center experience over a two-decade period
Jean-Jacques Patard1, Hicham Tazi, Karim Bensalah
1Service d'Urologie, CHU Pontchaillou, rue Henri Le Guilloux, 35033 Rennes, France. jean-jacques.patard2@libertysurf.fr
Objectives:
To study the evolution of renal tumours treated in a single institution over a 2-decade period.
Material And Methods:
729 patients surgically treated due to a renal tumour were included in this study. Age at diagnosis, gender, tumour size, TNM stage, percentage (%) of benign tumours, type of treatment, histologic subtype and mode of presentation were compared over 3 periods (1984-1992, 1993-1997, and 1998-2003).
Results:
During the period of the study, the median tumour size decreased from 7.5 to 6 cm while the rate of nephron-sparing surgery (NSS) increased from 1.6 to 19.6% and from 3.1 to 46.9% in all tumours and in tumours measuring less than 4 cm respectively. In this former group, the percentage of benign tumours increased from 6.3 to 15.2% while the percentage of radical nephrectomies decreased from 100% to 54.2%.
Conclusion:
We are treating today a great amount of small good prognosis renal tumors as well as an increasing percentage of benign tumours. In both cases, expanding the role of NSS will significantly reduce the rate of useless radical nephrectomies.
