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Related Experiment Videos

The human obesity gene map: the 2003 update.

Eric E Snyder1, Brandon Walts, Louis Pérusse

  • 1Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808-4124, USA.

Obesity Research
|March 27, 2004
PubMed
Summary

The tenth update of the human obesity gene map reviews over 430 genes, markers, and regions linked to obesity. This comprehensive map aids in understanding genetic factors contributing to obesity.

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Area of Science:

  • Genetics
  • Obesity Research
  • Genomics

Background:

  • The human obesity gene map provides a comprehensive overview of genetic factors associated with obesity.
  • Previous updates have cataloged genes, quantitative trait loci (QTLs), and chromosomal regions linked to obesity phenotypes.

Purpose of the Study:

  • To present the tenth update of the human obesity gene map, incorporating data up to October 2003.
  • To review evidence from various genetic studies, including Mendelian disorders, QTLs, and candidate gene associations.

Main Methods:

  • Systematic review of published literature up to October 2003.
  • Inclusion of data from single-gene mutations, Mendelian syndromes, human genome-wide scans, animal crossbreeding experiments, and candidate gene studies.
  • Incorporation of data from transgenic and knockout murine models relevant to obesity.

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Main Results:

  • 41 Mendelian syndromes relevant to human obesity have been mapped, with causal genes identified for most.
  • 183 QTLs reported from animal models and 208 human QTLs for obesity phenotypes identified.
  • Over 430 genes, markers, and chromosomal regions associated or linked with human obesity phenotypes cataloged, with 15 candidate genes supported by at least five studies.

Conclusions:

  • The human obesity gene map continues to expand, with putative loci identified on all chromosomes except Y.
  • The comprehensive map serves as a valuable resource for researchers investigating the genetic basis of obesity.
  • Ongoing research is increasingly focused on relating DNA sequence variation in specific genes to obesity phenotypes.