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Related Experiment Videos

Relationship between respiratory control and feeding in the developing infant.

Martha J Miller1, Pakaphan Kiatchoosakun

  • 1Rainbow Babies and Children's Hospital, Division of Neonatology, 11100 Euclid Avenue, Cleveland, OH 44106-6010, USA. mjm8@po.cwru.edu

Seminars in Neonatology : SN
|March 31, 2004
PubMed
Summary

Infant feeding coordination involves complex muscle control for breathing and swallowing. While typically developed by 35 weeks, respiratory issues can interfere, and reflux doesn

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pediatrics

Background:

  • Simultaneous breathing and feeding (suck-swallow-breathe) requires intricate muscle coordination.
  • This coordination involves the brainstem controlling buccopharyngeal and esophageal phases of feeding.
  • Development of these functions is generally complete by 35 weeks post-conceptional age but can be affected by pathology.

Purpose of the Study:

  • To elucidate the neural control mechanisms underlying infant feeding and respiration.
  • To understand the developmental trajectory of coordinated breathing and swallowing.
  • To investigate the relationship between gastro-oesophageal reflux and apnoea of prematurity.

Main Methods:

  • Review of neurophysiological mechanisms controlling deglutition and respiration.

Related Experiment Videos

  • Analysis of developmental milestones in infant feeding and swallowing.
  • Examination of the role of the brainstem in regulating feeding reflexes and esophageal function.

    • Main Results:

    • Brainstem nuclei control sequential muscle activity during the buccopharyngeal phase of feeding.
    • Lower esophageal sphincter tone is regulated by brainstem nuclei and modulated by respiratory drive.
    • Gastro-oesophageal reflux does not appear to be a common trigger for apnoea of prematurity.

    Conclusions:

    • Coordinated breathing and feeding in infants rely on complex brainstem circuitry.
    • Disruptions in respiratory or neurological function can impair infant feeding coordination.
    • While reflux can be symptomatic, it is not a primary cause of apnoea in premature infants.