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Updated: Aug 9, 2026

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium
Published on: July 8, 2015
Total synthesis of (+)-muconin
Takehiko Yoshimitsu1, Toshiyuki Makino, Hiroto Nagaoka
1Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan. takey@my-pharm.ac.jp
Abstract:
(+)-Muconin (1), isolated from the leaves of Rollinia mucosa (Jacq.) Baill. (Annonaceae), is a sequential THF/THP-possessing acetogenin that exhibits potent and selective in vitro cytotoxicity toward pancreatic and breast tumor cell lines. In this study, a new route was established for obtaining (+)-muconin (1) starting with (-)-muricatacin (2), a compound recently synthesized via the novel alpha-C-H hydroxyalkylation and alpha'-C-H oxidation of tetrahydrofuran.
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