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Updated: Aug 13, 2026
The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects
Published on: October 2, 2014
No deterioration after 13 years in a stability study of a rabbit brain, plain, thromboplastin, RBT 1010, in
K J Stevenson1, S Craig, L Goodman
1Haematology Research Unit, Department of Clinical Laboratory Medicine, Wythenshawe Hospital, Manchester M23 9LT, UK. ken.stevenson@smuht.nwest.nhs.uk
Abstract:
RBT 1010, a rabbit brain thromboplastin, plain, was prepared at the Thrombosis Reference Centre, Withington Hospital, Manchester, in 1989. The batch has been stored at -20 degrees C, in rubber-stoppered ampoules, for 13 years. The material was unchanged after this time. This was confirmed in a stability study, in which the reagent was used to test the prothrombin times of a panel of plasmas stored in liquid nitrogen, one from a normal volunteer and two from stable anticoagulated patients. RBT 1010 was also tested in calibrations, according to World Health Organization recommendations, against the reference thromboplastin preparations CRM 149S and RBT 90.
