Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Centrosomes: hooked on the nucleus.

Pierre Gönczy1

  • 1ISREC, 155, ch. des Boveresses, CH-1066 Epalinges / Lausanne, Switzerland. Pierre.Gonczy@isrec.unil.ch

Current Biology : CB
|April 6, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Development of the fluorescent probe CenSpark for labeling centrioles and cilia.

Nature chemical biology·2026
Same author

Development of the fluorescent probe CenSpark for labeling centrioles and cilia.

Nature chemical biology·2026
Same author

Critical constituents and assembly principles of centriole biogenesis in human cells.

Nature reviews. Molecular cell biology·2025
Same author

C. elegans SAS-1 ensures centriole integrity and ciliary function, and operates with SSNA-1.

PLoS genetics·2025
Same author

One-shot design of functional protein binders with BindCraft.

Nature·2025
Same author

BindCraft: one-shot design of functional protein binders.

bioRxiv : the preprint server for biology·2024
Same journal

Increased rates of hybridization in swordtails are associated with water pollution.

Current biology : CB·2026
Same journal

Visual uncertainty and task demands shape active sensing strategies in mice.

Current biology : CB·2026
Same journal

An adaptable, self-organizing, single-cell morphology circuit optimizes suctorian predatory trap structure.

Current biology : CB·2026
Same journal

Temporal tuning of switch-like virulence expression resolves environmental uncertainty through phenotypic heterogeneity.

Current biology : CB·2026
Same journal

An abstract relational map emerges in the human medial prefrontal cortex with consolidation.

Current biology : CB·2026
Same journal

Phloem evolved gradually and asynchronously to xylem in early vascular plants.

Current biology : CB·2026
See all related articles

The Hook protein ZYG-12 in Caenorhabditis elegans is crucial for connecting the centrosome to the nucleus. This discovery reveals a new mechanism for how these organelles attach and their importance.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Background:

  • The centrosome and nucleus are critical organelles in eukaryotic cells.
  • Understanding the mechanisms that link these organelles is vital for cell function.

Purpose of the Study:

  • To investigate the role of the Hook protein ZYG-12 in Caenorhabditis elegans.
  • To elucidate the mechanism of centrosome-nucleus attachment.

Main Methods:

  • Utilized genetic analysis in Caenorhabditis elegans.
  • Investigated the function of the ZYG-12 protein.

Main Results:

  • The Hook protein ZYG-12 was found to be essential for centrosome-nucleus attachment.
  • Demonstrated a novel mechanism for the physical coupling of the centrosome and nucleus.

Related Experiment Videos

Conclusions:

  • ZYG-12 plays a key role in the structural integrity and function of the cell.
  • The findings provide new insights into organelle interactions and their biological significance.