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[The possible nephrotoxicity of a bituminous coal dermatologic agent]
M C Wright1, A Kaufhold, F Hevert
1Basotherm GmbH, Biberach, Johann Wolfgang Goethe-Universität Frankfurt a.M.
Summary
This study found Berniter, a modern coal tar scalp preparation, does not cause kidney damage. Renal function tests and urinary phenol levels remained normal in healthy volunteers after 8 weeks of use.
Area of Science:
- Dermatology
- Nephrology
- Toxicology
Background:
- Coal tar preparations are used for dermatological conditions.
- Concerns exist regarding potential nephrotoxic effects of coal tar.
- A modern coal tar preparation for scalp use, Berniter, required safety evaluation.
Purpose of the Study:
- To assess the renal tolerance of Berniter, a coal tar preparation for the scalp.
- To investigate potential nephrotoxic effects associated with Berniter application.
Main Methods:
- A renal tolerance study was conducted on 15 healthy volunteers.
- Volunteers applied Berniter using three different application modes over 4-8 weeks.
- Renal function and urinary phenol levels were monitored before, during, and after treatment.
Main Results:
- No pathological changes or impairment of renal functions were detected in any application mode.
- Urinary phenol levels showed no correlation with Berniter treatment.
- The study found no evidence of nephrotoxicity.
Conclusions:
- The investigated coal tar preparation, Berniter, demonstrates no nephrotoxic properties.
- Berniter appears to be safe for renal function when used as directed for scalp conditions.
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