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Bovine viral diarrhea virus in embryo and semen production systems

M Daniel Givens1, Julie G Waldrop

  • 1Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, 129 Sugg Laboratory, Auburn, AL 36849-5516, USA. givenmd@vetmed.auburn.edu

The Veterinary Clinics of North America. Food Animal Practice
|April 6, 2004
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Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...