Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Common variable immunodeficiency and breast cancer.

Apurva C Mehta1, Kathy Faber-Langendoen, David B Duggan

  • 1Department of Medicine, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY 13210, USA.

Cancer Investigation
|April 9, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasmablastic Lymphoma or Plasmablastic Myeloma: A Case of Post-Transplant Lymphoproliferative Disorder.

Case reports in hematology·2021
Same author

Speaking Up: An Ethical Action Exercise.

Academic medicine : journal of the Association of American Medical Colleges·2017
Same author

Every error a treasure: improving medication use with a nonpunitive reporting system.

Joint Commission journal on quality and patient safety·2007
Same author

Rituximab-induced interstitial lung disease.

American journal of hematology·2007
Same author

Deception, discrimination, and fear of reprisal: lessons in ethics from third-year medical students.

Academic medicine : journal of the Association of American Medical Colleges·2005
Same author

Great expectations.

Cancer investigation·2003
Same journal

Analysis of Second Primary Tumours in Cutaneous Lymphoma Populations.

Cancer investigation·2026
Same journal

The Heterogeneity of B Cells Potentially Contributes to Metastasis of Clear Cell Renal Cell Carcinomas.

Cancer investigation·2026
Same journal

The Association Between Lymphocyte-Monocyte Ratio, Tumor-Infiltrating Lymphocytes, and Tumor-Associated Macrophages with 3-Year Progression-Free Survival in Advanced Local Stage Nasopharyngeal Cancer Patients.

Cancer investigation·2026
Same journal

<i>In Vivo</i> Pharmacokinetics, Bio-Distribution and anti-Tumor Activity of Docetaxel-Loaded Folate Targeted Biocompatible Polymeric Micelles.

Cancer investigation·2026
Same journal

Bispecific Antibodies in Multiple Myeloma: A Concise Review of Current Treatments.

Cancer investigation·2026
Same journal

Adrenal Carcinoma Laterality is of Limited Clinical Significance: A National Perspective.

Cancer investigation·2026
See all related articles

Two young women diagnosed with early-onset breast cancer also had common variable immunodeficiency (CVID). This suggests a potential link between CVID and breast cancer in premenopausal women, warranting further investigation.

Area of Science:

  • Immunology
  • Oncology
  • Genetics

Background:

  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low antibody levels and recurrent infections.
  • Early-onset breast cancer (EOC) affects women typically under age 40 and has a lower incidence compared to later-onset breast cancer.

Observation:

  • Two patients presented with early-onset breast cancer (ages 31 and 38).
  • Both patients had a documented history of frequent and unusual bacterial infections, a common symptom of CVID.

Findings:

  • The co-occurrence of EOC and CVID in these patients is notable given the low individual incidences of both conditions.
  • The shared diagnosis suggests a potential pathophysiological link or causal relationship between CVID and the development of breast cancer.

Related Experiment Videos

Implications:

  • This case series highlights a potential association between CVID and an increased risk of early-onset breast cancer.
  • Further research is warranted to explore the underlying mechanisms and genetic factors that may connect CVID and breast cancer development.
  • Consideration of immune status may be important in the risk assessment and management of young women diagnosed with breast cancer.