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[Renal and tissue fibrinolysis dysfunction in secondary pyelonephritis in children before and after the surgery]

B M Bodnar, A V Irynchyn, V L Brozhyk

    Klinichna Khirurhiia
    |April 13, 2004
    PubMed

    Insights

    Children with obstructive pyelonephritis undergoing surgery may experience reduced urine urokinase activity. This can lead to blood clots and hydronephrosis, requiring further medical intervention.

    Area of Science:

    • Urology
    • Pediatric Nephrology
    • Biochemistry

    Context:

    • Secondary pyelonephritis in children often results from obstructive uropathy.
    • Surgical intervention is common for obstructive pyelonephritis.
    • Understanding post-operative physiological changes is crucial for pediatric urological care.

    Purpose:

    • To investigate changes in blood and urine fibrinolytic and proteolytic activity in children with secondary pyelonephritis.
    • To analyze tissue fibrinolytic activity in the pyelourethral segment before and after surgery.
    • To evaluate the impact of operative treatment on urodynamics and coagulation potential.

    Summary:

    • Operative treatment for obstructive pyelonephritis in children can lead to decreased urine urokinase activity.
    • Post-surgery, impaired tissue fibrinolysis in the pyelourethral segment and increased general hemocoagulative potential are observed.
    • These changes create conditions favoring the development of urolithiasis and hydronephrosis.

    Impact:

    • Highlights the risk of secondary complications like urolithiasis and hydronephrosis after pyelonephritis surgery.
    • Emphasizes the need for monitoring and correcting urodynamic and coagulation disorders post-operatively.
    • Informs clinical practice regarding long-term management of pediatric obstructive pyelonephritis.

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