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Bone biopsy as a screening technique for bone bank allograft donation
Saqib A Siddiqui1, Jeffrey F Lipton, Vincent J Vigorita
1Division of Orthopaedic Surgery, Kingsbrook Jewish Medical Center, Brooklyn, New York, USA.
American Journal of Orthopedics (Belle Mead, N.J.)
|April 13, 2004
Summary
Histomorphometry of bone allografts can detect occult hematological and metabolic bone diseases missed by standard screening. Iliac crest bone biopsy may enhance donor screening for improved allograft effectiveness.
Area of Science:
- Orthopedics
- Pathology
- Hematology
Background:
- Current screening for bone allograft donors (history, serology, culture) may miss occult pathologies.
- Identifying unsuspected conditions in donors can improve allograft effectiveness and patient outcomes.
Purpose of the Study:
- To investigate occult abnormalities in bone allografts using histomorphometry.
- To assess the utility of histomorphometry beyond current screening methods for bone donors.
Main Methods:
- Prospective pathology review of 40 transcortical trephine bone biopsies from iliac crests.
- Examination via light microscopy and semiautomated histomorphometry.
Main Results:
- Light microscopy identified one case suspicious for chronic myeloproliferative disorder, undetected by standard screening.
- Histomorphometric analysis revealed severe osteoporosis in 3 specimens.
Conclusions:
- Iliac crest bone biopsy with histomorphometry can detect unsuspected hematological and metabolic bone diseases.
- Bone biopsy may serve as an adjunct screening tool for bone allograft donors.