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Updated: Aug 24, 2026

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Published on: February 17, 2018
Dual antegrade response tachycardia induced cardiomyopathy
Deepak Gaba1, Behzad B Pavri, Arnold J Greenspon
1Department of Medicine, Division of Cardiovascular Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Abstract:
We report a rare case of tachycardia induced cardiomyopathy resulting from nearly incessant dual antegrade response tachycardia. Criteria necessary for sustaining dual antegrade responses are discussed, including: (1) sufficient antegrade dissociation of the AV node; (2) absence of retrograde conduction over each AV nodal pathway following antegrade conduction over its counterpart; (3) difference between fast and slow pathway conduction times exceeding His-Purkinje refractoriness; and (4) critical timing of sinus impulses relative to preceding AV nodal conduction. Both the arrhythmia and cardiomyopathy were successfully treated by slow pathway ablation.
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