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Updated: Aug 24, 2026

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology
Published on: September 13, 2022
[Anti-arrhythmia activity of derinat in an experiment]
O I Sviatkina1, V P Balashov, L A Balykova
1Department of Pharmacology, Mordvinian State University, ul. Bol'shevistskaya 68, Saransk, Mordvinia, 430000 Russia.
Abstract:
The acute toxicity of the immunostimulant derinat is very low: the LD50 value for intraperitoneal administration exceeds 1000 mg/kg. The drug effectively prevents from acute arrhythmia development upon occlusion in cats and produces antifibrillator effect on a model of reperfusive arrhythmia in a dose of 7.5 mg/kg. Derinat also exhibits the antiarrhythmic activity on the model of adrenalin-induced rhythm violations, but appears ineffective on the calcium chloride model.
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