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Related Experiment Videos

Initial experience with the Toronto Root bioprosthesis.

Tirone E David1, Friedrich W Mohr, Joseph E Bavaria

  • 1Cardiac Surgical Programs, Toronto General Hospital, Toronto, ON, Canada. tirone.david@uhn.on.ca

The Journal of Heart Valve Disease
|April 17, 2004
PubMed
Summary
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The Toronto Root bioprosthesis is safe and effective for aortic valve or root replacement. Early results show excellent hemodynamics and patient improvement, with no valve-related deaths.

Area of Science:

  • Cardiovascular Surgery
  • Bioprosthetic Valves
  • Aortic Valve Replacement

Background:

  • The Toronto Root bioprosthesis is a novel device for aortic root and valve replacement.
  • Early postoperative safety and efficacy data are crucial for clinical adoption.

Purpose of the Study:

  • To evaluate the safety and efficacy of the Toronto Root bioprosthesis in early postoperative stages.
  • To assess hemodynamic performance and patient outcomes following aortic procedures.

Main Methods:

  • A multicenter study involving 191 patients implanted with the Toronto Root bioprosthesis between 2000 and 2002.
  • Echocardiography and serum aluminum level monitoring were performed pre- and postoperatively, with a six-month follow-up.
  • Procedures included full aortic root, root inclusion, and subcoronary implantations, with or without concomitant coronary artery bypass grafting.

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Main Results:

  • No valve-related deaths occurred in 191 patients; all survivors showed symptomatic improvement (97% in NYHA class I/II at 6 months).
  • Hemodynamic assessment revealed a mean effective orifice area of 2.0 cm² and a mean systolic gradient of 7.0 mmHg at six months.
  • Complications included two reoperations for technical errors, two cases of endocarditis, and two transient ischemic attacks; serum aluminum levels remained unchanged.

Conclusions:

  • The Toronto Root bioprosthesis demonstrates early safety and efficacy for aortic valve or root replacement.
  • The bioprosthesis exhibits favorable hemodynamic characteristics, including a large effective orifice area and low transvalvular gradient.
  • These findings support the Toronto Root bioprosthesis as a viable option for aortic procedures.