Related Experiment Video
Updated: Aug 24, 2026
Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
Published on: May 16, 2022
[Distribution of calcitonin gene-related peptide in guinea pig cochlea]
Benming Qi1, Xiang Huang, Liangru Zhu
1Department of Otolaryngology, First People's Hospital of Yunnan Province, Kunming, 650001, China.
Objective:
To observe the distribution of CGRP in guinea pig cochlea.
Method:
CGRP was labeled by immunostaning technique. Distribution of CGRP immunoreactivity was observed with light microscopy.
Result:
CGRP immunoreactivity was located in SGN, nerve fibers at osseous spiral lamina, stria vascularis, IHC, adjacent area of OHC and Deiters' cells.
Conclusion:
CGRP distributes extensively in guinea pig cochlea. CGRP may play an important role as neurotransmitter and/or neuromodulator to hearing function by modulating HC, supporting cells, SGN and other neurons along the process of auditory nerve. It may have effect on on cochlear blood flow, too.
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