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Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: July 1, 2013
Seronegative infection and AIDS caused by an A2 subsubtype HIV-1
Ana R Cardoso1, Cristina Gonçalves, Dulce Pascoalinho
1Hospital Nossa Senhora da Graça, Tomar, Portugal.
Abstract:
The study of true seronegative HIV-1 infections may have important implications for the diagnosis and prevention of HIV-1 infection. The case of an AIDS patient with persistently negative HIV serology is described. Genetic and phylogenetic analysis indicated that she was infected with A2 subsubtype HIV-1 transmitted by her seropositive and asymptomatic sexual partner. The clinical and serological discordant results suggest the presence of an immunological deficiency that prevents the formation of HIV-1-specific antibodies.
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