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Fixed-volume metering microdispenser module
Aniruddha Puntambekar1, Jin-Woo Choi, Chong H Ahn
1Department Electrical and Computer Engineering, University of Cincinnati, Cincinnati, OH 45221-0030, USA.
Lab on a Chip
|April 22, 2004
Summary
We developed a novel microdispenser using structurally programmable microfluidic systems (sPROMs) technology for precise liquid handling. This innovation offers high accuracy and repeatability for lab-on-a-chip devices.
Area of Science:
- Microfluidics
- Biotechnology
- Nanotechnology
Background:
- Accurate and repeatable dispensing of small liquid volumes is crucial for lab-on-a-chip devices.
- Existing microdispensing technologies face challenges in achieving precise volume control and integration.
Purpose of the Study:
- To introduce a novel fixed-volume metering microdispenser module.
- To demonstrate the capabilities of structurally programmable microfluidic systems (sPROMs) technology for microdispensing applications.
Main Methods:
- Design, simulation, fabrication, and characterization of microdispenser arrays.
- Utilizing sPROMs technology for fixed-volume liquid metering.
- Extensive simulations to analyze passive microvalves and air-driven liquid column splitting.
- Development of a technique for sub-microliter volume unloading.
Main Results:
- Fabricated microdispensers with volumes ranging from 50 nL to 150 nL.
- Achieved high accuracy (99.2%) and excellent repeatability.
- Validated key microdispenser components through simulation and experimental characterization.
Conclusions:
- The novel sPROMs-based microdispenser module offers a robust solution for precise liquid handling.
- The developed microdispensers are suitable for integration into lab-on-a-chip devices.
- The technology enables accurate and repeatable dispensing of nanoliter volumes.