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Detecting and quantifying apoptosis in tissue sections.

Vicki Save1, Peter A Hall, Philip J Coates

  • 1Department of Pathology, Addenbrookes Hospital, Cambridge University, UK.

Methods in Molecular Biology (Clifton, N.J.)
|April 24, 2004
PubMed
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This review covers methods for identifying apoptosis, or programmed cell death, in tissues and cells. It highlights DNA-end labeling techniques for accurate cell analysis and quantification.

Area of Science:

  • Cell Biology
  • Histopathology

Background:

  • Apoptosis is a crucial biological process.
  • Accurate identification of apoptotic cells is vital for research and diagnostics.

Purpose of the Study:

  • To review various techniques for identifying apoptosis in biological samples.
  • To emphasize the utility of in situ end-labeling methods.

Main Methods:

  • Review of established methods including simple morphology and electron microscopy.
  • Detailed discussion of DNA-end labeling techniques.
  • Exploration of immunochemical approaches for apoptosis detection.

Main Results:

  • Multiple techniques are available for apoptosis identification.
  • In situ end-labeling offers a sensitive and specific approach.

Related Experiment Videos

  • Methods for analyzing and quantifying apoptotic cells are presented.

    • Conclusions:

    • A range of methods exist for detecting apoptosis.
    • In situ end-labeling is a key technique for analysis and quantification.
    • Understanding these methods aids in biological and pathological studies.