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Updated: Aug 24, 2026
Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Synthesis and biodistribution of (99m)Tc-carbonyltechnetium-labeled fatty acids
Taiwei Chu1, Yu Zhang, Xinqi Liu
1Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PR China. twchu@pku.edu.cn
Abstract:
In order to image myocardial metabolism, (99m)Tc(CO)(3)(+) complexes containing fatty acids were evaluated. At first, 11-(1-imidazolyl)-undecanoic acid (IUA) and 11-(2-(4-bromo-phenylazo)-1-imidazolyl)-undecanoic acid (BPIUA) were synthesized and the corresponding carbonyltechnetium-labeled complexes were prepared. However, unfortunately similar to those of other technetium-labeled fatty acid analogs, the biodistribution studies of (99m)Tc(CO)(3)-IUA and (99m)Tc(CO)(3)-BPIUA in mice demonstrated poor heart-to-blood ratios, thus these complexes cannot be used as heart-imaging reagents. In addition, Tween-80 can improve the biodistribution of the complexes for myocardial imaging.
