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Real-time Imaging of Single Engineered RNA Transcripts in Living Cells Using Ratiometric Bimolecular Beacons
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Photobleaching microscopy reveals the dynamics of mRNA-binding proteins inside live cell nuclei

José Braga1, José Rino, Maria Carmo-Fonseca

  • 1Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, 1649-028, Lisbon, Portugal.

Progress in Molecular and Subcellular Biology
|April 29, 2004
PubMed
Abstract

No abstract available in PubMed .

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Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...