Mixed infection with unusual fungi and staphylococcal species in two extremely premature neonates

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Updated: Aug 24, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Akhil Maheshwari1, Carine I Stromquist, Lourdes Pereda

  • 1Division of Neonatology, Department of Pediatrics, All Children's Hospital and University of South Florida College of Medicine, St Petersburg/Tampa, FL 33701, USA.

Journal of Perinatology : Official Journal of the California Perinatal Association
|April 30, 2004
PubMed

Insights

Systemic fungal infections are increasingly seen in premature infants. This study highlights two cases of mixed Staphylococcal and fungal infections, emphasizing the need for fungal infection consideration in neonates with skin lesions.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Mycology

Background:

  • Systemic fungal infections are a growing concern in extremely premature neonates.
  • Staphylococcal infections and fungal pathogens can co-occur, posing diagnostic challenges.

Observation:

  • Two cases of extremely premature neonates presented with late-onset mixed infections.
  • Infections involved Staphylococcal species and unusual fungi.

Findings:

  • Damaged skin may serve as an entry point for fungal pathogens, potentially exacerbated by Staphylococcal interactions.
  • Fungal infection should be considered in sick premature infants with necrotic skin lesions, even with concurrent bacteremia.

Implications:

  • Early recognition and consideration of fungal infections are crucial for managing sick premature infants.
  • Understanding pathogen interactions can inform preventative strategies and treatment protocols for neonatal sepsis.

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