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Related Experiment Videos

Periodic alternating esotropia.

L M Hamed1, J Silbiger

  • 1Department of Ophthalmology, University of Florida, College of Medicine, Gainesville 32610-0284.

Journal of Pediatric Ophthalmology and Strabismus
|July 1, 1992
PubMed
Summary
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Periodic alternating esotropia (PAE) is a rare eye movement disorder. This study details a case in a young girl with cerebellar hypoplasia, linking PAE with periodic alternating gaze deviation.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pediatrics

Background:

  • Periodic alternating esotropia (PAE) is a rare ocular motility disturbance.
  • It is typically associated with periodic alternating gaze deviation (PAG) or periodic alternating nystagmus.

Observation:

  • A 9-month-old developmentally delayed female infant presented with synchronous PAE and PAG.
  • The disorder involved rhythmic alternating fixation, face turns, and esotropia lasting approximately 90 seconds per phase, with a brief neutral phase.
  • No spontaneous nystagmus was observed during an 18-month follow-up.

Findings:

  • Magnetic resonance imaging revealed significant cerebellar vermis hypoplasia.
  • This case is one of only a few reported with PAE and PAG.
  • This is the first reported case studied with modern neuroimaging.

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Implications:

  • This case highlights the association between cerebellar vermis hypoplasia and synchronous PAE and PAG.
  • It underscores the importance of advanced neuroimaging in understanding rare ocular motility disorders.
  • Further research may elucidate the pathophysiology linking cerebellar development to these specific eye movement abnormalities.