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Updated: Aug 24, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Applied biocatalysis for the synthesis of natural flavour compounds--current industrial processes and future
J Schrader1, M M W Etschmann, D Sell
1Karl Winnacker Institute, DECHEMA e.V., Theodor-Heuss-Allee 25, 60486 Frankfurt/Main, Germany. schrader@dechema.de
Abstract:
The industrial application of biocatalysis for the production of natural flavour compounds is illustrated by a discussion of the production of vanillin, gamma-decalactone, carboxylic acids, C6 aldehydes and alcohols ('green notes'), esters, and 2-phenylethanol. Modern techniques of molecular biology and process engineering, such as heterologous expression of genes, site-directed mutagenesis, whole-cell biocatalysis in biphasic systems, and cofactor regeneration for in vitro oxygenation, may result in more biocatalytic processes for the production of flavour compounds in the future.
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