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Rapid HPLC method for the determination of paclitaxel in pharmaceutical forms without separation
Irinel Badea1, Dana Ciutaru, Lelia Lazar
1Sindan Pharmaceutical Co., 11 Ion Mihalache Blvd. 78168, Bucharest, Romania. irinel_badea@yahoo.com
Abstract:
A HPLC method has been developed for the in-process determination of the paclitaxel from dosage pharmaceutical forms. This method ensures the rapid determination of paclitaxel in the presence of polyoxyl castor oil--the main constituent of paclitaxel's clinical formulation vehicle. The method is simple and rapid and does not require any preliminary treatment of the sample. The method was fully validated.
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