Related Experiment Video
Updated: Aug 24, 2026
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Expression of PTEN protein in oromaxillofacial tumor cell lines]
Bin Liu1, Jun-zheng Wu, Xiao-hong Duan
1Department of Oral Biology, College of Stomatology, Fourth Military Medical University, Xi'an 710032, China. kqyljd@fmmu.edu.cn
Aim:
To investigate expression of PTEN protein in oromaxillofacial tumor cell lines and to compare the difference of PTEN protein expression between highly metastatic cancer cell lines and their parent cell lines.
Methods:
ABC immunohistochemical staining was applied for detecting expression of PTEN protein in 8 kinds of cancer cell lines, including tongue cancer cell lines Tca8113 and HSC-3,oral bottom cancer cell line HSC-2, buccal cancer cell line BcaCD885, mucoepidermoid carcinoma cell line MEC-1, adenoid cystic carcinoma cell line SACC83, highly metastatic tongue cancer cell line Tb-TLP and highly metastatic mucoepidermoid carcinoma cell line M3SP2.
Results:
Of the 8 kinds of cancer cell lines, 5 kinds of cancer cell lines were positive for PTEN protein expression. PTEN protein was located in cytoplasm around nucleus. 3 kinds of cancer cell lines, BcaCD885, Tb-TLP and M3SP2, lacked expression of PTEN protein.
Conclusion:
Deficiency of PTEN protein expression may play a certain role in cancer cell metastasis.
