Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transfusion in pediatrics.

Lars Desmet1, Jacques Lacroix

  • 1Department of Pediatrics, Faculté de Médecine, Université de Montreal, Quebec, Canada.

Critical Care Clinics
|May 12, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Platelet Transfusion Thresholds for Children Supported by Extracorporeal Membrane Oxygenation: The Extracorporeal Membrane Oxygenation Hemostatic Transfusions in Children (ECSTATIC) Feasibility Clinical Trial.

Critical care medicine·2025
Same author

Pilot-Optimizing Transfusion Therapy in Critically Ill Children With Anemia: A Pilot Multicenter Electronic Health Record-Enabled Randomized Controlled Trial on Red Blood Cell Transfusion in Critically Ill Children.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2025
Same author

Is It the Right Time to Recommend a Liberal RBC Transfusion Strategy in Children With Severe Acute Brain Injury?

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2025
Same author

Human Papillomavirus Persistence, Recurrence, and Incidence in Early Childhood.

The Journal of infectious diseases·2025
Same author

Viral Load of Human Papillomavirus (HPV) During Pregnancy and Its Association With HPV Vertical Transmission.

Journal of medical virology·2025
Same author

Larger versus smaller red blood cell volume per transfusion in hospitalized adults, children, and preterm neonates.

The Cochrane database of systematic reviews·2024
Same journal

Critical Care and Contagion: Evolving Frontiers of Infectious Diseases in the Modern Intensive Care Unit.

Critical care clinics·2026
Same journal

Advances and Challenges in Sepsis Care in Low-Resource Settings.

Critical care clinics·2026
Same journal

The Respiratory Triple Pandemic in the Intensive Care Unit: Epidemiology, Clinical Features and Management of COVID-19, Influenza and Respiratory Syncytial Virus.

Critical care clinics·2026
Same journal

Antibiotic Stewardship for the Intensivist.

Critical care clinics·2026
Same journal

Infection Prevention and Control in the Intensive Care Unit.

Critical care clinics·2026
Same journal

Antibiotic Considerations in the Critically Ill: Empiric Choices and Dosing.

Critical care clinics·2026
See all related articles

Critical care for children requires more research on red blood cell (RBC) transfusions due to practice variations and limited evidence. New studies are needed to address anemia and transfusion safety in critically ill children.

Area of Science:

  • Pediatric Critical Care Medicine
  • Transfusion Medicine
  • Hematology

Background:

  • Significant variation exists in stated versus observed red blood cell (RBC) transfusion practices among pediatric critical care practitioners and in published guidelines.
  • There is a notable lack of clinical evidence regarding RBC transfusion in critically ill children.
  • Existing adult trial data is not generalizable to pediatric populations due to physiological and disease process differences.

Purpose of the Study:

  • To highlight the need for more research on anemia and RBC transfusion in critically ill children.
  • To underscore the limitations of generalizing adult transfusion trial data to pediatric critical care.
  • To advocate for further investigation into transfusion practices, epidemiology, prevention, and alternatives in pediatric intensive care units (PICUs).

Related Experiment Videos

Main Methods:

  • Literature review to identify variations in transfusion practices and guidelines.
  • Analysis of existing evidence, noting the single adult randomized trial.
  • Identification of knowledge gaps concerning RBC transfusion in critically ill children.

Main Results:

  • Observed significant discrepancies between recommended and actual RBC transfusion practices in pediatric critical care.
  • Identified a scarcity of robust clinical evidence specific to RBC transfusion in critically ill children.
  • Concluded that adult transfusion trial results cannot be extrapolated to pediatric populations.

Conclusions:

  • Further research is imperative to establish optimal anemia management and RBC transfusion strategies for critically ill children.
  • The TRIPICU study is investigating transfusion safety in stable critically ill children.
  • Future research should encompass transfusion epidemiology, prevention, and alternatives like erythropoietin in PICUs.