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Published on: October 12, 2017

A serum amyloid A and LDL complex as a new prognostic marker in stable coronary artery disease

Ken Ogasawara1, Shinichi Mashiba, Youichiro Wada

  • 1The Cardiovascular Institute, Roppongi 7-3-10 Minato-ku, Tokyo 106-0032, Japan. ij3k-ogsw@asahi-net.or.jp

Atherosclerosis
|May 12, 2004
PubMed

Insights

The SAA/LDL complex, a novel inflammatory marker, shows greater sensitivity than CRP or SAA in predicting prognosis for patients with stable coronary artery disease (CAD). This finding offers a new tool for risk stratification in cardiovascular disease management.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Inflammation Research

Background:

  • Prognostic value of acute phase proteins like CRP and SAA in acute coronary syndrome is known.
  • The predictive capability of these inflammatory markers in stable coronary artery disease (CAD) remains unclear.
  • This study aimed to clarify the prognostic significance of inflammatory markers in stable CAD patients.

Purpose of the Study:

  • To evaluate the prognostic value of serum amyloid A/low-density lipoprotein (SAA/LDL) complex in patients with stable coronary artery disease (CAD).
  • To compare the predictive power of SAA/LDL complex against established markers like C-reactive protein (CRP) and serum amyloid A (SAA).

Main Methods:

  • Prospective cohort study of 140 patients with stable CAD.
  • Measurement of serum SAA/LDL complex using sandwich ELISA, alongside CRP and SAA levels.
  • Defined endpoints included cardiac death, myocardial infarction, cerebral infarction, and coronary revascularization.

Main Results:

  • 21 endpoint events occurred during the study period.
  • Independent predictors of adverse events included age, diabetes mellitus, triglyceride levels, and SAA/LDL complex concentration.
  • SAA/LDL complex (per 10 microg/ml) showed an odds ratio of 2.32 (CI: 1.05-4.70) for event occurrence.
  • Reconstitution experiments indicated SAA/LDL complex formation via oxidative interaction between SAA and lipoproteins.

Conclusions:

  • The SAA/LDL complex directly reflects intravascular inflammation.
  • SAA/LDL complex serves as a novel, sensitive marker for predicting prognosis in stable CAD patients.
  • This marker demonstrates superior predictive capability compared to CRP or SAA in this patient population.
Abstract

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