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Updated: Aug 24, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
Published on: December 2, 2016
Aldosterone and cardiovascular remodelling: focus on myocardial failure
Frederick K Shieh1, Eugene Kotlyar, Flora Sam
1Boston University Medical School, Boston University Medical Center, Boston, Massechussetts, USA.
Abstract:
Heart failure is a clinical syndrome that may result from different disease states or conditions that injure the myocardium. The activation of circulating neurohormones, particularly aldosterone, may play a pivotal role in left ventricular (LV) remodelling. The Randomized Aldactone Evaluation Study and Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival trial have emphasised the clinical importance of aldosterone. This review addresses some of the proposed mechanisms of LV remodelling in heart failure.
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