Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does looping and clustering in the nucleus regulate gene expression?

Séverine Chambeyron1, Wendy A Bickmore

  • 1MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, Scotland, UK.

Current Opinion in Cell Biology
|May 18, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disease-associated genetic variants can cause missense effects in tissue-specific protein isoforms.

Nature communications·2026
Same author

Host-transposable element coexistence: a matter of resistance, tolerance and trade-off.

The EMBO journal·2026
Same author

Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites.

eLife·2026
Same author

A nowhere-to-hide mechanism ensures complete piRNA-directed DNA methylation.

Nature·2026
Same author

Enhancer cooperativity in the folded genome.

Current opinion in genetics & development·2025
Same author

Is enhancer-driven gene regulation all wrapped up?

Nature reviews. Genetics·2025
Same journal

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
See all related articles

Chromatin looping organizes DNA within the nucleus, influencing gene expression. These looped domains concentrate proteins, facilitating gene activation and repression.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • The spatial organization of chromatin within the cell nucleus is of significant interest.
  • Understanding chromatin organization is crucial for comprehending gene expression and its regulation.

Purpose of the Study:

  • To explore the role of looped chromatin domains in nuclear organization.
  • To investigate how spatial chromatin organization influences gene expression.
  • To examine the function of nuclear compartments in protein modification.

Main Methods:

  • Utilized new molecular techniques to identify looped chromatin domains.
  • Studied specific genetic loci, including mammalian beta-globin and Drosophila hsp70.
  • Investigated the spatial clustering of sequences from the Drosophila bithorax complex.

Related Experiment Videos

Main Results:

  • Identified looped chromatin domains at key genetic loci.
  • Demonstrated that looped domains can insulate chromatin and concentrate nuclear proteins.
  • Showed spatial clustering of trans-located sequences, suggesting coordinated gene regulation.

Conclusions:

  • Bringing DNA and proteins together in defined nuclear sub-regions facilitates gene expression control.
  • Nuclear compartments play a role in organizing chromatin and regulating gene activity.
  • Nuclear compartments may be involved in post-translational protein modifications like sumoylation and ubiquitylation.