Laboratory evaluation of the patient with erectile dysfunction

Erectile dysfunction (ED) as a clinical entity is a problem that more than 50% of men will face as they age, and it can adversely affect overall quality of life and impact sexual partners. Our understanding of the pathophysiology and the multiple risk factors that contribute to ED has led to successful treatments, both non- surgical and surgical, over the past two decades. Now, more nonurologists and primary care providers are seeing patients for their initial evaluation. It is imperative that they approach the workup and evaluation in a logical and efficient manner. After a thorough history and physical examination, followed by a relevant and systematic laboratory evaluation, most cases can be effectively identified and medical treatment can be initiated. However, patients who continue to have erectile difficulties or fail initial oral treatment are candidates for specialized evaluation of vascular, neurogenic, and hormonal dysfunction, which can lead to more specific treatment or possible surgical management.