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Updated: Aug 24, 2026
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
[The effect of substituting latanoprost 0.005% for unoprostone 0.12%]
Yasumasa Otori1, Hideki Tokugawa, Hiroyuki Morimura
1Department of Ophthalmology and Visual Science, Osaka University Medical School, 2-2 Yamadaoka, Suita 565-0871, Japan.
Purpose:
To evaluate the effect of substituting latanoprost(LAT) 0.005% for unoprostone(UNO) 0.12% after a trial of unilateral treatment.
Methods:
We treated 30 patients with primary open-angle glaucoma(n = 8), ocular hypertension (n = 1), or normal-tension glaucoma(n = 21) with UNO for 4 weeks in one eye and then substituted LAT for UNO. Four weeks later we measured the intraocular pressure(IOP) in the ipsilateral eye.
Results:
The mean baseline IOP level was 18.6 +/- 3.8(mean +/- standard deviation) mmHg. The mean IOP levels(reduction rates) after UNO and LAT therapy were 16.7 +/- 3.1 mmHg (16.6%) and 14.1 +/- 3.2 mmHg (28.9%), respectively(p < 0.001). All patients who responded to UNO also responded to LAT; however, 55% of those who did not respond to UNO responded to LAT.
Conclusions:
If LAT is substituted for UNO, it can be predicted that 63.3% of the patients will respond.
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